[3H]-thioperamide as a radioligand for the histamine H3 receptor in rat cerebral cortex
نویسندگان
چکیده
منابع مشابه
assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
چکیده ندارد.
15 صفحه اولHistamine H3 Receptor-Mediated Signaling Protects Mice from Cerebral Malaria
BACKGROUND Histamine is a biogenic amine that has been shown to contribute to several pathological conditions, such as allergic conditions, experimental encephalomyelitis, and malaria. In humans, as well as in murine models of malaria, increased plasma levels of histamine are associated with severity of infection. We reported recently that histamine plays a critical role in the pathogenesis of ...
متن کاملEvaluation of 11C-GSK189254 as a novel radioligand for the H3 receptor in humans using PET.
UNLABELLED The histamine H(3) receptor is implicated in the pathophysiology of several central nervous system disorders. N-methyl-6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-nicotamide (GSK189254) is a highly potent, selective, and brain-penetrant H(3) receptor antagonist. Previous studies in the pig using PET have shown that (11)C-GSK189254 uptake in H(3)-rich regions of the ...
متن کاملEffects of administration of histamine and its H1, H2, and H3 receptor antagonists into the primary somatosensory cortex on inflammatory pain in rats
Objective(s): The present study investigated the effects of microinjection of histamine and histamine H1, H2, and H3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (PSC) on inflammatory pain. Material and Methods: Two stainless steel guide canulas were bilaterally implanted into the PSC of anaesthetized rats. Inf...
متن کاملبررسی اثر آگونیست و آنتاگونیست های مختلف گیرنده هیستامینی بر هماهنگی حرکتی موش صحرایی در تست Rota rod
Background and purpose: Sedation is regarded as a common side effect of most antihistamines, and limits the clinical utility of classical antihistaminic agents, while newer antihistamines are nonsedating. Çonsidering the importance of this phenomenon in the present study, the role of different histamine receptor mechanisms in mediating the sedation were investigated in rat rota rod test. M...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1996
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1996.tb15642.x